Co-localization of Human Growth Hormone and Human Prolactin in Hormonally Pure Human Growth Hormone-producing Pituitary Adenomas
نویسندگان
چکیده
منابع مشابه
Pituitary adenomas producing growth hormone in acromegalic patients.
Growth hormone was shown in histological sections of 25 pituitary adenomas from acromegalic patients by means of the unlabelled peroxidase-antiperoxidase (PAP) technique. On the basis of the numbers of cytoplasmic granules, the cells of the adenomas were of two types: densely granulated and sparsely granulated. The densely granulated cells had abundant cytoplasm containing numerous granules, wh...
متن کاملImmunochemical investigations of human pituitary growth hormone.
Earlier immunological investigations of growth hormone (somatotropin) isolated from bovine and human pituitaries showed that these two protein hormone preparations form speciesspecific antibodies, as evidenced by the results of precipitin ring tests with rabbit antiserum and of anaphylactic shock experiments in guinea pigs (1, 2). It was further demonstrated that the rabbit antiserum exerts in ...
متن کاملProlactin (PRL)-releasing peptide stimulates PRL secretion from human fetal pituitary cultures and growth hormone release from cultured pituitary adenomas.
The hypothalamic peptide PRL-releasing peptide (PrRP) has recently been cloned and identified as a ligand of an orphan pituitary receptor that stimulates in vitro PRL secretion. PrRP also induces PRL release in rats in vivo, especially in normal cycling females. However, no information on the effects of PrRP in the human is available. To elucidate the role of PrRP in regulating human anterior p...
متن کاملState of human growth hormone in plasma and changes in stored solutions of pituitary growth hormone.
Radioimmunoassay of endogenous plasma growth hormone in human plasma fractions separated by starch gel electrophoresis shows that the plasma hormone migrates in a fairly narrow peak behind serum albumin. A similar electrophoretic mobility is exhibited by certain pituitary growth hormone preparations (the A type of Wilhehni), added to plasma in physiological concentrations or on electrophoresis ...
متن کاملInvestigation of Responsiveness to Thyrotropin-Releasing Hormone in Growth Hormone-Producing Pituitary Adenomas
Objective. The aim of this study was to investigate how the paradoxical response of GH secretion to TRH changes according to tumor volumes. Methods. Patients with newly diagnosed acromegaly were classified as either TRH responders or nonresponders according to the results of a TRH stimulation test (TST), and their clinical characteristics were compared according to responsiveness to TRH and tum...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurologia medico-chirurgica
سال: 1998
ISSN: 0470-8105,1349-8029
DOI: 10.2176/nmc.38.335